http://shootout.alioth.debian.org/u32q/benchmark.php?test=all&lang=python3
So not only is Python 3 needlessly incompatible and requires a bunch of annoying code changes, it's also slower and uses more memory. (Unless you happen to do a lot of Mandelbrot set calculations.)
What the fuck, GWEEDO.
I tried C#, was a bit too verbose for my tastes. IronPython is pretty zippy, though. And having access to all the CLR goodness was a blast.
However, when all is said and done, I prefer C-compiled programs over bytecode or interpreted. Thus, Genie.